Susceptibility of house mouse carriers of Tyr139Cys and Leu128Ser/Tyr139Cys VKOR variants to difenacoum
Само за регистроване кориснике
2023
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
After the vkorc1 gene was first identified, changes occurring in the gene have been considered one of the main reasons of reduced susceptibility of house mice to anticoagulants. A no-choice feeding test was conducted according to standard EPPO (2004) methodology. Animals were fed for 21 days on baits containing difenacoum 0.005%. All animals were bromadiolone-resistant. Seven months earlier, all test animals had survived a 21-day bromadiolone (0.005%) no-choice feeding test, and sequencing of their vkorc1 gene had revealed the presence of Tyr139Cys and Leu1258Ser/Tyr139Cys VKOR variant. There were no survivors in the no-choice difenacoum feeding test. Consumption was not affected by VKOR variant, sex or genotype. A higher lethal dose was confirmed for Leu128Ser/Tyr139Cys than Tyr139Cys carriers, for females than males, and for homozygotes than heterozygotes. Our research showed that difenacoum 0.005% was effective against house mice carrying the Tyr139Cys VKOR variant, whether it occur...red independently or in combination with the Leu128Ser variant in the Vkorc1 gene.
Кључне речи:
Vkorc1 / resistance / mutation / house mouse / DifenacoumИзвор:
International Journal of Pest Management, 2023, 69, 2, 103-108Издавач:
- Abingdon : Taylor & Francis
Пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200214 (Институт за пестициде и заштиту животне средине, Београд) (RS-MESTD-inst-2020-200214)
DOI: 10.1080/09670874.2020.1853277
ISSN: 0967-0874
WoS: 000596647900001
Scopus: 2-s2.0-85097109804
Институција
Institut za pesticide i zaštitu životne sredineTY - JOUR AU - Blažić, Tanja AU - Jokić, Goran AU - Esther, Alexandra AU - Đedović, Suzana PY - 2023 UR - https://ripest.pesting.org.rs/handle/123456789/16 AB - After the vkorc1 gene was first identified, changes occurring in the gene have been considered one of the main reasons of reduced susceptibility of house mice to anticoagulants. A no-choice feeding test was conducted according to standard EPPO (2004) methodology. Animals were fed for 21 days on baits containing difenacoum 0.005%. All animals were bromadiolone-resistant. Seven months earlier, all test animals had survived a 21-day bromadiolone (0.005%) no-choice feeding test, and sequencing of their vkorc1 gene had revealed the presence of Tyr139Cys and Leu1258Ser/Tyr139Cys VKOR variant. There were no survivors in the no-choice difenacoum feeding test. Consumption was not affected by VKOR variant, sex or genotype. A higher lethal dose was confirmed for Leu128Ser/Tyr139Cys than Tyr139Cys carriers, for females than males, and for homozygotes than heterozygotes. Our research showed that difenacoum 0.005% was effective against house mice carrying the Tyr139Cys VKOR variant, whether it occurred independently or in combination with the Leu128Ser variant in the Vkorc1 gene. PB - Abingdon : Taylor & Francis T2 - International Journal of Pest Management T1 - Susceptibility of house mouse carriers of Tyr139Cys and Leu128Ser/Tyr139Cys VKOR variants to difenacoum EP - 108 IS - 2 SP - 103 VL - 69 DO - 10.1080/09670874.2020.1853277 UR - conv_550 ER -
@article{ author = "Blažić, Tanja and Jokić, Goran and Esther, Alexandra and Đedović, Suzana", year = "2023", abstract = "After the vkorc1 gene was first identified, changes occurring in the gene have been considered one of the main reasons of reduced susceptibility of house mice to anticoagulants. A no-choice feeding test was conducted according to standard EPPO (2004) methodology. Animals were fed for 21 days on baits containing difenacoum 0.005%. All animals were bromadiolone-resistant. Seven months earlier, all test animals had survived a 21-day bromadiolone (0.005%) no-choice feeding test, and sequencing of their vkorc1 gene had revealed the presence of Tyr139Cys and Leu1258Ser/Tyr139Cys VKOR variant. There were no survivors in the no-choice difenacoum feeding test. Consumption was not affected by VKOR variant, sex or genotype. A higher lethal dose was confirmed for Leu128Ser/Tyr139Cys than Tyr139Cys carriers, for females than males, and for homozygotes than heterozygotes. Our research showed that difenacoum 0.005% was effective against house mice carrying the Tyr139Cys VKOR variant, whether it occurred independently or in combination with the Leu128Ser variant in the Vkorc1 gene.", publisher = "Abingdon : Taylor & Francis", journal = "International Journal of Pest Management", title = "Susceptibility of house mouse carriers of Tyr139Cys and Leu128Ser/Tyr139Cys VKOR variants to difenacoum", pages = "108-103", number = "2", volume = "69", doi = "10.1080/09670874.2020.1853277", url = "conv_550" }
Blažić, T., Jokić, G., Esther, A.,& Đedović, S.. (2023). Susceptibility of house mouse carriers of Tyr139Cys and Leu128Ser/Tyr139Cys VKOR variants to difenacoum. in International Journal of Pest Management Abingdon : Taylor & Francis., 69(2), 103-108. https://doi.org/10.1080/09670874.2020.1853277 conv_550
Blažić T, Jokić G, Esther A, Đedović S. Susceptibility of house mouse carriers of Tyr139Cys and Leu128Ser/Tyr139Cys VKOR variants to difenacoum. in International Journal of Pest Management. 2023;69(2):103-108. doi:10.1080/09670874.2020.1853277 conv_550 .
Blažić, Tanja, Jokić, Goran, Esther, Alexandra, Đedović, Suzana, "Susceptibility of house mouse carriers of Tyr139Cys and Leu128Ser/Tyr139Cys VKOR variants to difenacoum" in International Journal of Pest Management, 69, no. 2 (2023):103-108, https://doi.org/10.1080/09670874.2020.1853277 ., conv_550 .