UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations
2019
Authors
Savić, Jasmina Z.Petrović, Sandra Z.
Leskovac, Andreja R.
Lazarevic-Pasti, Tamara D.
Nastasijević, Branislav J.
Tanović, Brankica
Gašić, Slavica
Vasić, Vesna M.
Article (Accepted Version)
Metadata
Show full item recordAbstract
UV-C irradiation is widely used in the food industry. However, the health effects from dietary exposure to the irradiated pesticide residues retained in foodstuffs are underestimated. In this study, technical chlorpyrifos (TCPF) and its oil in water (EW) and emulsifiable concentrate (EC) formulations were irradiated by UV-C, and their photodegradation products were subjected to toxicity assessment, including determination of acetylcholinesterase (AChE) activity, genotoxicity and oxidative stress using human blood cells as a model system. Toxicity studies were performed using the chlorpyrifos concentrations in the range of those proposed as the maximum residue levels in plant commodities. TCPF, EW and EC photodegradation products induced DNA damage and oxidative stress, and their genotoxicity did not decrease as a function of irradiation time. Irradiated TCPF and EC are more potent AChE inhibitors than irradiated EW. Accordingly, the application of UV-C irradiation must be considered wh...en processing the plants previously treated with chlorpyrifos formulations.
Keywords:
Photodegradation / Oxidative stress / Genotoxicity / Chlorpyrifos / AcetylcholinesteraseSource:
Food Chemistry, 2019, 271, 469-478Publisher:
- ELSEVIER SCI LTD, OXFORD
Projects:
- Studies of enzyme interactions with toxic and pharmacologically active molecules (RS-MESTD-Basic Research (BR or ON)-172023)
Note:
- Published version: https://ripest.pesting.org.rs/handle/123456789/476
- This is the peer-reviewed version of the article: Savić, J. Z., Petrović, S. Z., Leskovac, A. R., Lazarevic-Pasti, T. D., Nastasijević, B. J., Tanović, B., Gašić, S., & Vasić, V. M. (2019). UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. Food Chemistry, 271, 469–478. https://doi.org/10.1016/j.foodchem.2018.07.207
Related info:
DOI: 10.1016/j.foodchem.2018.07.207
ISSN: 0308-8146
PubMed: 30236704
WoS: 000444967800061
Scopus: 2-s2.0-85050851053
Collections
Institution
Institut za pesticide i zaštitu životne sredineTY - JOUR AU - Savić, Jasmina Z. AU - Petrović, Sandra Z. AU - Leskovac, Andreja R. AU - Lazarevic-Pasti, Tamara D. AU - Nastasijević, Branislav J. AU - Tanović, Brankica AU - Gašić, Slavica AU - Vasić, Vesna M. PY - 2019 UR - https://ripest.pesting.org.rs/handle/123456789/566 AB - UV-C irradiation is widely used in the food industry. However, the health effects from dietary exposure to the irradiated pesticide residues retained in foodstuffs are underestimated. In this study, technical chlorpyrifos (TCPF) and its oil in water (EW) and emulsifiable concentrate (EC) formulations were irradiated by UV-C, and their photodegradation products were subjected to toxicity assessment, including determination of acetylcholinesterase (AChE) activity, genotoxicity and oxidative stress using human blood cells as a model system. Toxicity studies were performed using the chlorpyrifos concentrations in the range of those proposed as the maximum residue levels in plant commodities. TCPF, EW and EC photodegradation products induced DNA damage and oxidative stress, and their genotoxicity did not decrease as a function of irradiation time. Irradiated TCPF and EC are more potent AChE inhibitors than irradiated EW. Accordingly, the application of UV-C irradiation must be considered when processing the plants previously treated with chlorpyrifos formulations. PB - ELSEVIER SCI LTD, OXFORD T2 - Food Chemistry T1 - UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations EP - 478 SP - 469 VL - 271 DO - 10.1016/j.foodchem.2018.07.207 ER -
@article{ author = "Savić, Jasmina Z. and Petrović, Sandra Z. and Leskovac, Andreja R. and Lazarevic-Pasti, Tamara D. and Nastasijević, Branislav J. and Tanović, Brankica and Gašić, Slavica and Vasić, Vesna M.", year = "2019", abstract = "UV-C irradiation is widely used in the food industry. However, the health effects from dietary exposure to the irradiated pesticide residues retained in foodstuffs are underestimated. In this study, technical chlorpyrifos (TCPF) and its oil in water (EW) and emulsifiable concentrate (EC) formulations were irradiated by UV-C, and their photodegradation products were subjected to toxicity assessment, including determination of acetylcholinesterase (AChE) activity, genotoxicity and oxidative stress using human blood cells as a model system. Toxicity studies were performed using the chlorpyrifos concentrations in the range of those proposed as the maximum residue levels in plant commodities. TCPF, EW and EC photodegradation products induced DNA damage and oxidative stress, and their genotoxicity did not decrease as a function of irradiation time. Irradiated TCPF and EC are more potent AChE inhibitors than irradiated EW. Accordingly, the application of UV-C irradiation must be considered when processing the plants previously treated with chlorpyrifos formulations.", publisher = "ELSEVIER SCI LTD, OXFORD", journal = "Food Chemistry", title = "UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations", pages = "478-469", volume = "271", doi = "10.1016/j.foodchem.2018.07.207" }
Savić, J. Z., Petrović, S. Z., Leskovac, A. R., Lazarevic-Pasti, T. D., Nastasijević, B. J., Tanović, B., Gašić, S.,& Vasić, V. M.. (2019). UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry ELSEVIER SCI LTD, OXFORD., 271, 469-478. https://doi.org/10.1016/j.foodchem.2018.07.207
Savić JZ, Petrović SZ, Leskovac AR, Lazarevic-Pasti TD, Nastasijević BJ, Tanović B, Gašić S, Vasić VM. UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry. 2019;271:469-478. doi:10.1016/j.foodchem.2018.07.207 .
Savić, Jasmina Z., Petrović, Sandra Z., Leskovac, Andreja R., Lazarevic-Pasti, Tamara D., Nastasijević, Branislav J., Tanović, Brankica, Gašić, Slavica, Vasić, Vesna M., "UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations" in Food Chemistry, 271 (2019):469-478, https://doi.org/10.1016/j.foodchem.2018.07.207 . .